CASE REPORTS FOR FAECAL MICROBIOTA TRANSPLANTATION (FMT) IN HARROGATE DISTRICT HOSPITAL.

Abstract

The incidence of Clostridium difficile infection (CDI) has
increased approximately 20 fold over the past 20 years,
and rates are currently approximately 20 per 100,000
population. There are a number of risks factors for infection including antibiotic use, inflammatory bowel disease, co-morbidities and increasing age. Proton pump
inhibitors have also been implicated in CDI, although
this association remains controversial. The rising incidence of CDI has been associated with the emergence
of more pathogenic strains and this has led to an increase in mortality related to infection. The efficacy of
traditional antibiotic therapy for CDI has declined in recent years and this amplifies the problems of increasing
incidence and severity of the infection. A systemic review of cases series reported that there were 11 studies
involving 273 antibiotic resistant CDI patients and FMT
was successful in 89%.