In Celiac disease: Type 3a, 3b and grade BI is more frequent on Marsh Modified (Oberhuber) / Corraza classification.
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Abstract
Introduction: Histopathological alterations in celiac disease (CD)are villous atrophy, intraepithelial lymphocyte infiltration and crypt hyperplasia. It is caused by gluten in genetically predisposed persons. Duodenum and proximal part of jejunum are most commonly involved. Various classifications are used to define histopathological features of CD, but it is easier to define on Marsh modified (Oberhuber) Corraza classification.
Objective: The object of study is to differentiate histopathogical feature of celiac disease on Marsh modified (Oberhuber) and Corraza classifications
Methodology: This retrospective study of 66 cases of CD carried out at Muhammad Medical college Mirpurkhas Sindh Pakistan between January 2016 to December 2017. Fresh slides prepared and dually observed. All observations denoted and systemized on Marsh modified (Oberhuber) Corraza classification. There are many mimics of CD, they should be excluded for the proper approach to diagnosis.
Conclusion: Histopathogical finding are helpful in CD if they are carefully classified. Typing and grading system of Marsh modified Corraza classification is easier to define and is supportive to observe the features in diagnosis and prognosis of disease.
Key words: Celiac disease, Intraepithelial lymphocytes, villous atrophy. Histopathology, serology
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